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新药开发现状与前景《Drug Discovery and Development - Present and Future》

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Drug discovery and development process aims to make available medications that are safe and effective in improving the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, resource intensive, requiring multi-disciplinary expertise and innovative approaches. There is a growing urgency to identify and develop more effective, efficient, and expedient ways to bring safe and effective products to the market. The drug discovery and development process relies on the utilization of relevant and robust tools, methods, models, and validated biomarkers that are predictive of clinical effects in terms of diagnosis, prevention, therapy, and prognosis. There is a growing emphasis on translational research, a bidirectional bench to the bedside approach, in an effort to improve the process efficiency and the need for further innovations. The authors in the book discuss the current and evolving state of drug discovery and development.
Introductory Chapter  
Overview of Current Drug Discovery and Development with an Eye towards the Future
Chapter 1  
Drug Discovery and Ayurveda: Win-Win Relationship Between Contemporary and Ancient Sciences
Chapter 2  
Evolutionary Biology and Drug Development
Chapter 3  
Novel Oncology Drug Development Strategies in the Era of Personalised Medicine
Chapter 4  
Drug Discovery into the 21st Century
Chapter 5  
Genetically Engineered Mouse Models in Preclinical Anti-Cancer Drug Development
Chapter 6  
Genetic Pharmacotherapy
Chapter 7  
Critical Human Hepatocyte-Based In Vitro Assays for the Evaluation of Adverse Drug Effects
Chapter 8  
The Use of In Vitro 3D Cell Models in Drug Development for Respiratory Diseases
Chapter 9  
Chemical Biology: What is Its Role in Drug Discovery?
Chapter 10  
Towards Understanding Drugs on the Molecular Level to Design Drugs of Desired Profiles
Chapter 11  
De-Risking Drug Discovery Programmes Early with ADMET
Chapter 12  
Novel Approach to High Throughput Screening for Activators of Transcription Factors
Chapter 13  
Assessment of Cell Cycle Inhibitors by Flow Cytometry
Chapter 14  
Image-Based High-Content Screening in Drug Discovery
Chapter 15  
Recent Advances in Biotherapeutics Drug Discovery and Development
Chapter 16  
Drug Discovery by Aptamers in Protozoan Infectious Diseases
Chapter 17  
Streamlining ICH Q6B Analytical Testing of Biotherapeutics
Chapter 18  
Biomarkers in Drug Development: A Useful Tool but Discrepant Results May Have a Major Impact
Chapter 19  
Nanotechnology Based Targeted Drug Delivery: Current Status and Future Prospects for Drug Development
Chapter 20  
Silver Nanoparticles – Universal Multifunctional Nanoparticles for Bio Sensing, Imaging for Diagnostics and Targeted Drug Delivery for Therapeutic Applications
Chapter 21  
Mesenchymal Stem Cells as Vehicles for Targeted Therapies
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