书名COMPREHENSIVE
CHROMATOGRAPHY
IN COMBINATION WITH
MASS SPECTROMETRY
作者LUIGI MONDELLO
页数 490
出版社JOHN WILEY & SONS, INC., PUBLICATION
oBook ISBN: 9781118003466
ePDF ISBN: 9781118003442
ePub ISBN: 9781118003459
目录Contributors ix
Preface xi
1 Introduction 1
Luigi Mondello, Peter Q. Tranchida, and Keith D. Bartle
1.1 Two-Dimensional Chromatography–Mass Spectrometry:
A 50-Year-Old Combination, 2
1.2 Shortcomings of One-Dimensional Chromatography, 3
1.3 Benefits of Two-Dimensional Chromatography, 6
1.4 Book Content, 7
1.5 Final Considerations, 11
2 Multidimensional Gas Chromatography:
Theoretical Considerations 13
Leonid M. Blumberg
2.1 Symbols, 15
2.2 One-Dimensional GC, 17
2.3 Comprehensive GC × GC, 31
3 Multidimensional Liquid Chromatography:
Theoretical Considerations 65
Pavel Jandera
3.1 Two-Dimensional LC Techniques, 66
v
vi CONTENTS
3.2 Peak Capacity in HPLC: One- and Multidimensional
Separations, 69
3.3 Orthogonality in Two-Dimensional LC–LC Systems, 73
3.4 Sample Dimensionality and Structural Correlations, 75
3.5 Separation Selectivity and Selection of Phase Systems in
Two-Dimensional LC–LC, 79
3.6 Programmed Elution in Two-Dimensional HPLC, 81
3.7 Fraction Transfer Modulation in Comprehensive LC × LC:
Additional Band Broadening, 87
3.8 Future Perspectives, 89
4 History, Evolution, and Optimization Aspects of Comprehensive
Two-Dimensional Gas Chromatography 93
Ahmed Mostafa, Tadeusz G′orecki, Peter Q. Tranchida, and
Luigi Mondello
4.1 Fundamentals of GC × GC, 94
4.2 Modulation, 96
4.3 GC × GC Data Interpretation, 97
4.4 GC × GC Instrumentation, 100
4.5 Thermal Modulators, 101
4.6 Comprehensive Two-Dimensional GC Method Optimization, 115
4.7 Final Remarks, 140
5 Flow-Modulated Comprehensive Two-Dimensional Gas
Chromatography 145
John V. Seeley
5.1 Timing Requirements of GC × GC Modulators, 145
5.2 Criteria for Evaluating Modulators, 150
5.3 Forms of Modulation, 151
5.4 Single-Stage Flow Modulation, 152
5.5 Two-Stage Flow Modulation, 157
5.6 Summary of Flow Modulators, 167
5.7 Brief Comparison to Thermal Modulation, 169
5.8 Concluding Remarks, 169
6 Comprehensive Two-Dimensional Gas Chromatography
Combined with Mass Spectrometry 171
Peter Q. Tranchida, Luigi Mondello, Samuel D. H. Poynter, and
Robert A. Shellie
6.1 Instrument Requirements for GC × GC–MS, 173
6.2 Data Processing of GC × GC–TOF MS Results, 180
6.3 Method Translation in GC × GC–MS, 181
6.4 GC × MS, 181
CONTENTS
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