ÊéÃû Wiley Encyclopedia of Chemical Biology
×÷Õß Tadhg P. Begley
Ò³Êý 2514
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ISBN: 978©\0©\471©\75477©\0
Ŀ¼1 Applications of Chemical Biology
1.1 Biomaterials
Biocompatibility of Materials Used in Medical Devices, Methods For Evaluating 15
Controlled Drug Delivery: Pharmacokinetic Considerations, Methods and Systems 23
1.2 Biotechnology
Directed Evolution, Novel and Improved Enzymes through 33
1.3 Chemical Biology of Disease
Anxiety Disorders: Macromolecular Pathways and Interactions 43
Chronic Obstructive Pulmonary Disease (COPD), Inflammatory Mechanisms of 58
Depression, Chemical Mechanisms of 69
Hemozoin: A Paradigm for Biominerals in Disease 82
Hypoxic Response and Associated Diseases 93
Lysosomal Disorders 108
Metabolic Diseases, Biological Mechanisms of 119
Mitochondrial Medicine, Biochemical Evaluation of Mitochondrial Function 132
Protein Misfolding and Disease, Chemical Biology of 140
Protein Trafficking Diseases, Small Molecule Approaches to 153
Saliva in Health and Disease, Chemical Biology of 162
Schizophrenia, Biological Mechanisms of 171
Systems Approach to Studying Disease 181
1.4 Pharmacology and Drug Discovery
ADME Properties of Drugs 189
Allergy and Asthma, Small Molecules to Target 196
Lead Optimization in Drug Discovery 204
Metals in Medicine, Imaging Agents 213
Natural Products as Anticancer Agents 222
Pharmaceutical Industry, Biocatalysts and Chemocatalysts 234
Plant©\Derived Natural Products Research, Recent Progress in Drug Discovery Based on 249
Platinum Anticancer Drugs, Chemical Biology of 271
Programmed Cell Death as a Therapeutic Approach 281
RNA Interference to Treat Human Diseases, Applications of 289
Transcription©\Based Therapeutics 300
2 Biomolecules within the Cell
2.1 Glycans (Carbohydrates)
Chemistry of Neoglycoproteins 310
Glycan Biosynthesis in Mammals 320
Glycosphingolipids, Chemistry of 336
Starch Biosynthesis In Plants 356
2.2 Lipids
Chemistry of Lipid Domains 371
Essential Fatty Acids, Physiologic and Clinical Significance of 376
Lipid Bilayers, Properties of 395
Lipids, Chemical Diversity of 410
Lipids, Organization and Aggregation of 424
Lipids, Phase Transitions of 437
2.3 Natural Products
Alkaloid Biosynthesis 452
Chlorophylls and Carotenoids, Chemistry of 468
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